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Index > Protein center > Met(Gene name) > Rat
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  • Met (Gene name),
  • Hepatocyte growth factor receptor (Protein name ),  MET_RAT from NCBI database.
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  • Gene name:
    Met;
    Protein name:
    Hepatocyte growth factor receptor(HGF receptor);
    Alternative:
    Proto-oncogene c-Met;HGF/SF receptor;Tyrosine-protein kinase Met;Scatter factor receptor(SF receptor);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10.
    Function:
    Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1382
    Sequence:
    50:
    MKAPTALAPG | ILLLLLTLAQ | RSHGECKEAL | VKSEMNVNMK | YQLPNFTAET | 
    100:
    PIHNVVLPGH | HIYLGATNYI | YVLNDKDLQK | VSEFKTGPVV | EHPDCFPCQD | 
    150:
    CSSKANVSGG | VWKDNVNMAL | LVDTYYDDQL | ISCGSVNRGT | CQRHVLPPDN | 
    200:
    AADIQSEVHC | MFSPLAEEES | GQCPDCVVSA | LGAKVLLSEK | DRFINFFVGN | 
    250:
    TINSSYPPDY | SLHSISVRRL | KETQDGFKFL | TDQSYIDVLP | EFRDSYPIKY | 
    300:
    IHAFESNHFI | YFLTVQKETL | DAQTFHTRII | RFCSVDSGLH | SYMEMPLECI | 
    350:
    LTEKRRKRST | REEVFNILQA | AYVSKPGANL | AKQIGASPYD | DILYGVFAQS | 
    400:
    KPDSAEPMNR | SAVCAFPIKY | VNDFFNKIVN | KNNVRCLQHF | YGPNHEHCFN | 
    450:
    RTLLRNSSGC | EVRSDEYRTE | FTTALQRVDL | FMGRLNHVLL | TSISTFIKGD | 
    500:
    LTIANLGTSE | GRFMQVVLSR | TAHFTPHVNF | LLDSYPVSPE | VIVEHPSNQN | 
    550:
    GYTLVVTGKK | ITKIPLNGLG | CGHFQSCSQC | LSPPYFIQCG | WCHNRCVHSN | 
    600:
    ECPSGTWTQE | ICLPAVYKVF | PTSAPLEGGT | MLTICGWDFG | FKKNNKFDLR | 
    650:
    KTKVLLGNES | CTLTLSESTT | NTLKCTVGPA | MSEHFNVSVI | VSNSRETTQY | 
    700:
    SAFSYVDPVI | TSISPRYGPH | AGGTLLTLTG | KYLNSGNSRH | ISIGGKTCTL | 
    750:
    KSVSDSILEC | YTPGHTVSAE | FPVKLKIDLA | DRVTSSFSYR | EDPVVSEIHP | 
    800:
    TKSFISGGST | ITGIGKNLNS | VSTPKLVIEV | HDVGVNYTVA | CQHRSSSEII | 
    850:
    CCTTPSLRQL | DLQLPLKTKA | FFLLDGILSK | HFDLTYVHDP | MFKPFEKPVM | 
    900:
    ISMGNENVVE | IKGDDIDPEA | VKGEVLKVGN | KSCENLHWHS | EALLCTVPSD | 
    950:
    LLKLNGGELN | IEWKQAVSST | VLGKVIVQPD | QNFAGLIIGA | VSISVVVLLV | 
    1000:
    SGLFLWLRKR | KHKDLGSELV | RYDARVHTPH | LDRLVSARSV | SPTTEMVSNE | 
    1050:
    SVDYRATFPE | DQFPNSSQNG | ACRQVQYLLT | DLSPILTSGD | SDISSPLLQN | 
    1100:
    TVHIDLSALN | PELVQAVPHV | VIGPSSLIVH | FNEVIGRGHF | GCVYHGTLLD | 
    1150:
    SDGKKIHCAV | KSLNRITDIE | EVSQFLTEGI | IMKDFSHPNV | LSLLGICLRS | 
    1200:
    EGSPLVVLPY | MKHGDLRNFI | RNETHNPTVK | DLIGFGLQVA | KGMKYLVSKK | 
    1250:
    FVHRDLAARN | CMLDEKFTVK | VADFGLARDM | YDKEYYSVHN | KTGAKLPVKW | 
    1300:
    MALESLQTQK | FTTKSDVWSF | GVLLWELMTR | GAPPYPDVNT | FDITIYLLQG | 
    1350:
    RRLLQPEYCP | DALYEVMLKC | WHPKAEMRPS | VSELVSRISS | IFSTFIGEHY | 
    1382:
    VHVNATYVNV | KCVAPYPSLL | PSQDNIDGEA | NT
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    String:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
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    Polyclonal Antibody for Rat HGF receptor
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    Polyclonal Antibody for Rat HGF receptor
    Monoclonal Antibody for Rat HGF receptor
    Monoclonal Antibody for Rat HGF receptor
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    Monoclonal Antibody for Rat HGF receptor
    Monoclonal Antibody for Rat HGF receptor
    Monoclonal Antibody for Rat HGF receptor
    Monoclonal Antibody for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor
    Protein for Rat HGF receptor

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    References
    1. 1.
      "Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA."
      Wallenius V.R. , Rawet H. , Skrtic S. , Helou K. , Qiu Y. , Levan G. , Ekberg S. , Carlsson B. , Isaksson O.G.P. , Nakamura T. , Jansson J.-O.
      Mamm. Genome8:661-667(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Sprague-Dawley.
      tissue: Liver.
    2. 2.
      "Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells."
      Liu Y. , Tolbert E.M. , Sun A.M. , Dworkin L.D.
      Am. J. Physiol.271:F679-F688(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
      strain: Sprague-Dawley.
      tissue: Kidney.
    3. 3.
      "Increased expression of c-met messenger RNA following acute gastric injury in rats."
      Tsujii M. , Kawano S. , Tsuji S. , Ito T. , Hayashi N. , Horimoto M. , Mita E. , Nagano K. , Masuda E. , Hayashi N. , Fusamoto H. , Kamada T.
      Biochem. Biophys. Res. Commun.200:536-541(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 364-495
      strain: Sprague-Dawley.
      tissue: Gastric mucosa.
    4. 4.
      "Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution."
      Pepper M.S. , Soriano J.V. , Menoud P.-A. , Sappino A.-P. , Orci L. , Montesano R.
      Exp. Cell Res.219:204-210(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 851-1002
      tissue: Intestine.
    5. 5.
      Kikuchi Y.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1129-1267
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