Protein name:
Hepatocyte growth factor receptor (HGF receptor) ;
Alternative:
Proto-oncogene c-Met ;HGF/SF receptor ;Tyrosine-protein kinase Met ;Scatter factor receptor (SF receptor) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1357, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation. Interacts with GRB10.
Function:
Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MKAPTALAPG | ILLLLLTLAQ | RSHGECKEAL | VKSEMNVNMK | YQLPNFTAET |
100:
PIHNVVLPGH | HIYLGATNYI | YVLNDKDLQK | VSEFKTGPVV | EHPDCFPCQD |
150:
CSSKANVSGG | VWKDNVNMAL | LVDTYYDDQL | ISCGSVNRGT | CQRHVLPPDN |
200:
AADIQSEVHC | MFSPLAEEES | GQCPDCVVSA | LGAKVLLSEK | DRFINFFVGN |
250:
TINSSYPPDY | SLHSISVRRL | KETQDGFKFL | TDQSYIDVLP | EFRDSYPIKY |
300:
IHAFESNHFI | YFLTVQKETL | DAQTFHTRII | RFCSVDSGLH | SYMEMPLECI |
350:
LTEKRRKRST | REEVFNILQA | AYVSKPGANL | AKQIGASPYD | DILYGVFAQS |
400:
KPDSAEPMNR | SAVCAFPIKY | VNDFFNKIVN | KNNVRCLQHF | YGPNHEHCFN |
450:
RTLLRNSSGC | EVRSDEYRTE | FTTALQRVDL | FMGRLNHVLL | TSISTFIKGD |
500:
LTIANLGTSE | GRFMQVVLSR | TAHFTPHVNF | LLDSYPVSPE | VIVEHPSNQN |
550:
GYTLVVTGKK | ITKIPLNGLG | CGHFQSCSQC | LSPPYFIQCG | WCHNRCVHSN |
600:
ECPSGTWTQE | ICLPAVYKVF | PTSAPLEGGT | MLTICGWDFG | FKKNNKFDLR |
650:
KTKVLLGNES | CTLTLSESTT | NTLKCTVGPA | MSEHFNVSVI | VSNSRETTQY |
700:
SAFSYVDPVI | TSISPRYGPH | AGGTLLTLTG | KYLNSGNSRH | ISIGGKTCTL |
750:
KSVSDSILEC | YTPGHTVSAE | FPVKLKIDLA | DRVTSSFSYR | EDPVVSEIHP |
800:
TKSFISGGST | ITGIGKNLNS | VSTPKLVIEV | HDVGVNYTVA | CQHRSSSEII |
850:
CCTTPSLRQL | DLQLPLKTKA | FFLLDGILSK | HFDLTYVHDP | MFKPFEKPVM |
900:
ISMGNENVVE | IKGDDIDPEA | VKGEVLKVGN | KSCENLHWHS | EALLCTVPSD |
950:
LLKLNGGELN | IEWKQAVSST | VLGKVIVQPD | QNFAGLIIGA | VSISVVVLLV |
1000:
SGLFLWLRKR | KHKDLGSELV | RYDARVHTPH | LDRLVSARSV | SPTTEMVSNE |
1050:
SVDYRATFPE | DQFPNSSQNG | ACRQVQYLLT | DLSPILTSGD | SDISSPLLQN |
1100:
TVHIDLSALN | PELVQAVPHV | VIGPSSLIVH | FNEVIGRGHF | GCVYHGTLLD |
1150:
SDGKKIHCAV | KSLNRITDIE | EVSQFLTEGI | IMKDFSHPNV | LSLLGICLRS |
1200:
EGSPLVVLPY | MKHGDLRNFI | RNETHNPTVK | DLIGFGLQVA | KGMKYLVSKK |
1250:
FVHRDLAARN | CMLDEKFTVK | VADFGLARDM | YDKEYYSVHN | KTGAKLPVKW |
1300:
MALESLQTQK | FTTKSDVWSF | GVLLWELMTR | GAPPYPDVNT | FDITIYLLQG |
1350:
RRLLQPEYCP | DALYEVMLKC | WHPKAEMRPS | VSELVSRISS | IFSTFIGEHY |
1382:
VHVNATYVNV | KCVAPYPSLL | PSQDNIDGEA | NT
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Dog
Mouse
Rat
Human
Rabbit
Pig
Bovine
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
ELISA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
CLIA Kit for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Polyclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Monoclonal Antibody for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
Protein for Rat HGF receptor
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA."
Wallenius V.R.
,
Rawet H.
,
Skrtic S.
,
Helou K.
,
Qiu Y.
,
Levan G.
,
Ekberg S.
,
Carlsson B.
,
Isaksson O.G.P.
,
Nakamura T.
,
Jansson J.-O.
Mamm. Genome8:661-667(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Sprague-Dawley .
tissue :
Liver .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION
strain :
Sprague-Dawley .
tissue :
Kidney .
3.
"Increased expression of c-met messenger RNA following acute gastric injury in rats."
Tsujii M.
,
Kawano S.
,
Tsuji S.
,
Ito T.
,
Hayashi N.
,
Horimoto M.
,
Mita E.
,
Nagano K.
,
Masuda E.
,
Hayashi N.
,
Fusamoto H.
,
Kamada T.
Biochem. Biophys. Res. Commun.200:536-541(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 364-495
strain :
Sprague-Dawley .
tissue :
Gastric mucosa .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 851-1002
tissue :
Intestine .
5.
Kikuchi Y.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1129-1267